Mesonephros development

Across TCGA cell cohorts, RNA activity of the Mesonephros development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZEB1, ESRP1, and LSR, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephros development activity versus ZEB1 in STOMACH (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZEB1 →	-3.473	-1.415	<.001	.002	3	11
STOMACH	ESRP1 →	+4.461	+1.294	.001	.005	3	9
LUNG_SCLC	LSR →	+2.615	+1.231	<.001	<.001	3	9
OVARY	GALNT3 →	+3.862	+1.448	<.001	.002	3	9
OVARY	PATJ →	+1.455	+1.308	<.001	<.001	3	9
LUNG_SCLC	MAP7 →	+2.243	+1.226	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001823 vs ZEB1 — STOMACH

Explore this scatter interactively →