Histamine secretion

Across TCGA patient cohorts, RNA activity of the Histamine secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIPA1, WIPF1, and ADA2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histamine secretion activity versus SIPA1 in LSCC (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SIPA1 →	+0.341	+0.062	<.001	<.001	3	7
OV	WIPF1 →	+0.292	+0.036	.003	.002	3	7
CCRCC	ADA2 →	+0.561	+0.060	<.001	<.001	3	7
OV	FNBP1 →	+0.394	+0.060	.001	<.001	3	7
LSCC	GIMAP8 →	+0.572	+0.057	<.001	<.001	3	7
GBM	HCLS1 →	+0.653	+0.078	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001821 vs SIPA1 — LSCC

Explore this scatter interactively →