Histamine secretion

Across TCGA patient cohorts, RNA activity of the Histamine secretion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF3R, LINC01888, and BCL2A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histamine secretion activity versus CSF3R in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CSF3R →	+1.522	+0.309	<.001	<.001	3	7
LSCC	LINC01888 →	+0.178	+0.197	<.001	<.001	3	7
UCEC	BCL2A1 →	+1.208	+0.269	<.001	<.001	3	6
UCEC	GBP5 →	+1.023	+0.218	.001	.007	3	6
BRCA	NCF1 →	+0.811	+0.264	<.001	<.001	3	6
UCEC	PTAFR →	+0.875	+0.277	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001821 vs CSF3R — LSCC

Explore this scatter interactively →