Histamine secretion

Across TCGA cell cohorts, RNA activity of the Histamine secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD2, ZNF66, and MPP7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FZD2 grouped by Histamine secretion-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FZD2 →	+1.016	+0.695	.002	.002	3	4
LIVER	ZNF66 →	+1.308	+1.565	<.001	<.001	3	4
BLOOD_Leukemia	MPP7 →	+1.933	+0.882	.001	.008	3	4
LIVER	ZNF724 →	+1.112	+1.943	.002	.001	3	4
BREAST	COL1A1 →	+1.288	+0.667	.001	.009	3	4
STOMACH	SHF →	+2.277	+1.198	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FZD2 by Histamine secretion activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →