Histamine secretion

Across TCGA cell cohorts, RNA activity of the Histamine secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BTK, DKC1, and DHX9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histamine secretion activity versus BTK in BLOOD_Leukemia (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BTK →	+0.883	+0.651	<.001	<.001	3	3
BLOOD_Lymphoma	DKC1 →	+0.356	+0.592	<.001	.009	3	3
BLOOD_Lymphoma	DHX9 →	+0.446	+0.752	<.001	.002	3	3
BLOOD_Lymphoma	GRB2 →	+0.527	+0.612	.002	.009	3	2
BLOOD_Lymphoma	LYN →	+1.385	+0.717	<.001	.002	3	2
BLOOD_Leukemia	SUPT4H1 →	+0.651	+0.750	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001821 vs BTK — BLOOD_Leukemia

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