Serotonin secretion

Across TCGA patient cohorts, RNA activity of the Serotonin secretion pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCL2, VAV1, and ZAP70, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin secretion activity versus PLCL2 in COAD (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLCL2 →	+0.577	+0.084	.001	.007	3	8
GBM	VAV1 →	+0.617	+0.162	<.001	<.001	3	7
LSCC	ZAP70 →	+0.586	+0.091	<.001	<.001	3	7
LSCC	DOCK11 →	+0.377	+0.120	<.001	<.001	3	7
LSCC	DOCK2 →	+0.613	+0.129	<.001	<.001	3	7
LSCC	DOCK8 →	+0.540	+0.130	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001820 vs PLCL2 — COAD

Explore this scatter interactively →