Serotonin secretion

Across TCGA cell cohorts, RNA activity of the Serotonin secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQGAP1, MYBL2, and CWC27, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IQGAP1 grouped by Serotonin secretion-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	IQGAP1 →	+0.292	+1.673	.001	<.001	3	6
STOMACH	MYBL2 →	+0.333	+1.161	.005	.003	2	7
LUNG_NSCLC_LUSC	CWC27 →	+0.396	+1.897	.004	<.001	3	5
OESOPHAGUS	PPP1R14A →	+0.129	+1.133	.004	.007	2	6
URINARY_TRACT	RCOR2 →	+0.307	+2.292	.002	<.001	3	4
PANCREAS	MAP4K3 →	-0.255	-1.593	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IQGAP1 by Serotonin secretion activity — STOMACH

Explore this box plot interactively →