Antibody-dependent cellular cytotoxicity

Across TCGA patient cohorts, RNA activity of the Antibody-dependent cellular cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR5, IL10RA, and FASLG, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antibody-dependent cellular cytotoxicity activity versus CCR5 in SKCM (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CCR5 →	+1.813	+0.108	<.001	<.001	3	32
SARC	IL10RA →	+1.667	+0.116	<.001	<.001	3	31
SKCM	FASLG →	+1.457	+0.102	<.001	<.001	3	31
SKCM	GPR65 →	+1.235	+0.106	<.001	<.001	3	31
SKCM	GBP5 →	+2.295	+0.110	<.001	<.001	3	31
SARC	C1QB →	+2.236	+0.112	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001788 vs CCR5 — SKCM

Explore this scatter interactively →