Antibody-dependent cellular cytotoxicity

Across TCGA patient cohorts, RNA activity of the Antibody-dependent cellular cytotoxicity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP4, LAP3, and LCP2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antibody-dependent cellular cytotoxicity activity versus GBP4 in BRCA (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBP4 →	+0.545	+0.044	<.001	<.001	3	10
UCEC	LAP3 →	+0.666	+0.150	<.001	<.001	3	10
GBM	LCP2 →	+0.487	+0.115	<.001	<.001	3	10
GBM	AIF1 →	+0.810	+0.166	<.001	<.001	3	9
HNSC	EVL →	+0.596	+0.104	<.001	<.001	3	9
BRCA	GBP5 →	+0.916	+0.059	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001788 vs GBP4 — BRCA

Explore this scatter interactively →