Natural killer cell proliferation

Across TCGA patient cohorts, RNA activity of the Natural killer cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALOX5, AIF1, and IL4I1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell proliferation activity versus ALOX5 in GBM (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALOX5 →	+0.759	+0.087	<.001	<.001	3	9
GBM	AIF1 →	+0.601	+0.074	<.001	<.001	3	9
UCEC	IL4I1 →	+0.688	+0.085	<.001	<.001	3	9
BRCA	PSMB10 →	+0.511	+0.040	<.001	<.001	3	9
GBM	PTPN6 →	+0.370	+0.048	.001	.001	3	9
LSCC	CCDC88B_S597 →	+1.034	+0.100	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001787 vs ALOX5 — GBM

Explore this scatter interactively →