Natural killer cell proliferation

Across TCGA cell cohorts, RNA activity of the Natural killer cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCUN1D3, CCDC9B, and HSPA8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCUN1D3 grouped by Natural killer cell proliferation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DCUN1D3 →	+0.849	+0.364	<.001	.004	3	3
OESOPHAGUS	CCDC9B →	+2.087	+0.408	.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	HSPA8 →	+1.372	+0.345	.005	.001	3	3
UPPER_AERODIGESTIVE_TRACT	NEBL →	-2.010	-0.393	.004	.006	3	3
LUNG_NSCLC_LUAD	SLC22A14 →	+0.130	+0.418	.006	.004	3	3
LUNG_NSCLC_LUSC	FBXO38 →	+0.551	+0.252	.006	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCUN1D3 by Natural killer cell proliferation activity — KIDNEY

Explore this box plot interactively →