B cell apoptotic process

Across TCGA patient cohorts, RNA activity of the B cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LIMD2, CTNND1, and DEF6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell apoptotic process activity versus LIMD2 in BRCA (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LIMD2 →	+0.494	+0.040	<.001	<.001	3	9
HNSC	CTNND1 →	-0.321	-0.061	<.001	<.001	3	8
GBM	DEF6 →	+0.514	+0.048	<.001	<.001	3	8
GBM	DOCK10 →	+0.442	+0.053	<.001	<.001	3	8
GBM	ABI3 →	+0.497	+0.050	<.001	<.001	3	8
LSCC	LPXN →	+0.445	+0.046	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001783 vs LIMD2 — BRCA

Explore this scatter interactively →