B cell apoptotic process

Across TCGA patient cohorts, RNA activity of the B cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, GJB1, and SIX4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell apoptotic process activity versus IRS2 in OV (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IRS2 →	+0.940	+0.858	.006	.003	3	9
CCRCC	GJB1 →	-0.853	-0.636	.001	.004	3	6
HNSC	SIX4 →	+0.806	+0.666	.005	.002	3	5
PDAC	DEGS2 →	-0.851	-0.895	<.001	<.001	3	5
GBM	RPS6KL1 →	-0.484	-0.188	.002	.006	3	5
GBM	WWP2 →	-0.355	-0.212	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001783 vs IRS2 — OV

Explore this scatter interactively →