B cell homeostasis

Across TCGA patient cohorts, RNA activity of the B cell homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAF3IP3, HCST, and CYTH4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell homeostasis activity versus TRAF3IP3 in LSCC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRAF3IP3 →	+0.696	+1.079	<.001	<.001	3	9
LSCC	HCST →	+0.676	+1.002	<.001	<.001	3	9
GBM	CYTH4 →	+0.795	+1.146	<.001	<.001	3	8
LSCC	NCF4 →	+0.808	+1.227	<.001	<.001	3	8
OV	CD37 →	+0.836	+0.794	.004	.002	3	8
GBM	CD33 →	+0.633	+1.156	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001782 vs TRAF3IP3 — LSCC

Explore this scatter interactively →