B cell homeostasis

Across TCGA cell cohorts, RNA activity of the B cell homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMS22L, CEP135, and PTPRZ1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell homeostasis activity versus MMS22L in BLOOD_Leukemia (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MMS22L →	-0.705	-0.686	.004	.009	3	3
BLOOD_Leukemia	CEP135 →	-0.855	-1.295	<.001	<.001	3	3
BLOOD_Lymphoma	PTPRZ1 →	+0.104	+0.688	.006	.007	3	2
BLOOD_Lymphoma	TRAPPC2B →	-1.145	-0.625	.002	.005	3	2
BLOOD_Leukemia	LRRC37A2 →	-0.697	-0.775	.004	.003	3	2
BLOOD_Leukemia	SULT1A3 →	-1.114	-1.164	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001782 vs MMS22L — BLOOD_Leukemia

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