Neutrophil apoptotic process

pathway activity — cross-omics
GO:0001781Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Neutrophil apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYBB, AMPD3, and ELMO1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADCYBB →+0.666+0.057<.001<.00138
GBMAMPD3 →+0.486+0.076<.001<.00138
GBMELMO1 →+0.498+0.091<.001<.00137
BRCARCSD1_S351 →+0.632+0.055<.001.00237
GBMSKAP2 →+0.603+0.088<.001<.00137
CCRCCCORO1A →+0.468+0.092<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration