Neutrophil homeostasis

Across TCGA patient cohorts, RNA activity of the Neutrophil homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEX3D, ACD, and CEACAM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil homeostasis activity versus MEX3D in COAD (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MEX3D →	-0.692	-1.345	<.001	<.001	3	4
GBM	ACD →	-0.352	-0.318	.001	.004	3	3
UCEC	CEACAM4 →	+0.617	+0.712	.001	.002	3	3
GBM	PIK3R2 →	-0.131	-0.382	.001	.002	3	3
GBM	NSD2 →	-0.402	-0.304	.009	.006	3	3
GBM	SYT7 →	-0.875	-0.249	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001780 vs MEX3D — COAD

Explore this scatter interactively →