Neutrophil homeostasis

Across TCGA cell cohorts, RNA activity of the Neutrophil homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2B2, TRMT5, and ANP32A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil homeostasis activity versus EIF2B2 in SKIN (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EIF2B2 →	+1.000	+0.332	<.001	.001	3	9
LARGE_INTESTINE	TRMT5 →	+0.656	+0.290	.004	.006	3	5
LARGE_INTESTINE	ANP32A →	+0.693	+0.267	.001	.007	3	5
OVARY	MTHFD1 →	+0.893	+0.300	.006	.007	2	6
URINARY_TRACT	IFT57 →	+0.865	+0.535	.002	<.001	3	5
URINARY_TRACT	TTLL5 →	+0.533	+0.492	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001780 vs EIF2B2 — SKIN

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