Natural killer cell differentiation

Across TCGA patient cohorts, RNA activity of the Natural killer cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S1PR1, DOCK8, and TNFAIP3, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell differentiation activity versus S1PR1 in CHOL (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	S1PR1 →	+1.463	+0.064	.002	<.001	3	32
SCLC	DOCK8 →	+1.767	+0.106	.003	<.001	3	31
DLBC	TNFAIP3 →	+2.064	+0.105	<.001	<.001	3	31
SCLC	ZEB2 →	+1.179	+0.087	<.001	<.001	3	31
DLBC	HEG1 →	+1.227	+0.079	<.001	.001	3	31
SCLC	TLR1 →	+1.319	+0.119	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001779 vs S1PR1 — CHOL

Explore this scatter interactively →