Natural killer cell differentiation

Across TCGA patient cohorts, RNA activity of the Natural killer cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIH1D2, SEMA4D, and NCR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell differentiation activity versus PIH1D2 in PDAC (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PIH1D2 →	-0.214	-0.465	.005	.003	3	4
CCRCC	SEMA4D →	+0.339	+0.474	.001	.001	3	3
PDAC	NCR1 →	+0.285	+0.573	.006	<.001	3	3
PDAC	BTBD6P1 →	+0.362	+0.404	<.001	.001	3	3
PDAC	CCL4 →	+0.449	+0.358	.003	.004	3	3
BRCA	WLS →	-1.212	-0.569	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001779 vs PIH1D2 — PDAC

Explore this scatter interactively →