Natural killer cell differentiation

Across TCGA cell cohorts, RNA activity of the Natural killer cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED9, LFNG, and CFAP300, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMED9 grouped by Natural killer cell differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMED9 →	-1.184	-1.491	.004	.007	3	6
BREAST	LFNG →	-1.870	-0.923	.001	.002	3	4
LARGE_INTESTINE	CFAP300 →	-0.879	-0.564	.004	.005	3	4
URINARY_TRACT	FCN3 →	-0.170	-2.114	.001	<.001	3	3
LUNG_NSCLC_LUSC	SLC22A17 →	-2.330	-1.374	.003	.002	3	3
UPPER_AERODIGESTIVE_TRACT	TIMP3 →	-3.206	-1.316	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMED9 by Natural killer cell differentiation activity — URINARY_TRACT

Explore this box plot interactively →