Plasma membrane repair

Across TCGA patient cohorts, RNA activity of the Plasma membrane repair pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM2_S1499, TRMT1, and GART, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane repair activity versus SRRM2_S1499 in LSCC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SRRM2_S1499 →	-0.555	-0.041	<.001	<.001	3	7
BRCA	TRMT1 →	-0.287	-0.029	.006	.003	3	7
LSCC	GART →	-0.238	-0.050	<.001	<.001	3	7
LSCC	CHAF1B_S410 →	-0.754	-0.049	<.001	<.001	3	6
COAD	NOLC1_S538 →	-0.610	-0.041	<.001	<.001	3	6
OV	POLD1 →	-0.294	-0.036	.008	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001778 vs SRRM2_S1499 — LSCC

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