Leukocyte homeostasis

Across TCGA patient cohorts, RNA activity of the Leukocyte homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, SH2B3, and ITGA4, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte homeostasis activity versus CSF2RB in CHOL (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	CSF2RB →	+2.156	+0.068	<.001	<.001	3	34
KICH	SH2B3 →	+1.341	+0.035	<.001	<.001	3	34
DLBC	ITGA4 →	+1.975	+0.051	<.001	<.001	3	34
UCS	IL18R1 →	+1.304	+0.045	<.001	<.001	3	34
SCLC	NCKAP1L →	+2.002	+0.096	<.001	<.001	3	34
SKCM	GPR65 →	+1.555	+0.059	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001776 vs CSF2RB — CHOL

Explore this scatter interactively →