Leukocyte homeostasis

Across TCGA patient cohorts, RNA activity of the Leukocyte homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and ARRB2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte homeostasis activity versus RCSD1 in GBM (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.645	+0.047	<.001	<.001	3	10
OV	RCSD1_S351 →	+0.653	+0.041	<.001	<.001	3	10
HNSC	ARRB2 →	+0.357	+0.068	<.001	<.001	3	10
LSCC	RGS19 →	+0.421	+0.072	<.001	<.001	3	10
COAD	RIN3 →	+0.475	+0.034	<.001	.002	3	10
OV	SAMSN1 →	+0.760	+0.046	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001776 vs RCSD1 — GBM

Explore this scatter interactively →