Leukocyte homeostasis

Across TCGA patient cohorts, RNA activity of the Leukocyte homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR171, NLRC3, and BTK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte homeostasis activity versus GPR171 in HNSC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GPR171 →	+0.684	+0.671	.004	.001	3	6
HNSC	NLRC3 →	+0.689	+0.718	.001	.003	3	5
BRCA	BTK →	+0.510	+0.883	.005	<.001	3	5
LSCC	IL2RA →	+0.860	+0.983	<.001	<.001	3	5
LSCC	DOCK2 →	+0.535	+0.708	<.001	<.001	3	5
LSCC	SIGLEC10 →	+0.913	+0.783	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001776 vs GPR171 — HNSC

Explore this scatter interactively →