Leukocyte homeostasis

Across TCGA cell cohorts, RNA activity of the Leukocyte homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMAB, TRANK1, and DDX60L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MMAB grouped by Leukocyte homeostasis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MMAB →	-1.047	-0.320	.007	<.001	3	5
CNS	TRANK1 →	+1.240	+0.257	<.001	.002	3	4
LUNG_SCLC	DDX60L →	+1.713	+0.197	.002	.006	3	4
LUNG_SCLC	FTSJ1 →	+0.570	+0.252	.002	.002	3	4
BREAST	TFIP11 →	+0.851	+0.135	.005	.004	3	4
BREAST	C16orf70 →	+0.445	+0.106	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MMAB by Leukocyte homeostasis activity — SOFT_TISSUE

Explore this box plot interactively →