Myeloid dendritic cell activation

Across TCGA patient cohorts, RNA activity of the Myeloid dendritic cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK2, FYB1, and HCLS1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid dendritic cell activation activity versus DOCK2 in UCEC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOCK2 →	+0.631	+0.093	<.001	<.001	3	10
GBM	FYB1 →	+0.633	+0.070	<.001	<.001	3	10
GBM	HCLS1 →	+0.680	+0.081	<.001	<.001	3	10
OV	ANKRD44 →	+0.540	+0.059	<.001	<.001	3	10
UCEC	ARHGAP25 →	+0.594	+0.111	<.001	<.001	3	10
UCEC	ARHGEF6 →	+0.476	+0.076	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001773 vs DOCK2 — UCEC

Explore this scatter interactively →