Myeloid dendritic cell activation

Across TCGA patient cohorts, RNA activity of the Myeloid dendritic cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD53, IKZF1, and BIN2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid dendritic cell activation activity versus CD53 in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD53 →	+0.585	+0.606	.009	.008	3	9
UCEC	IKZF1 →	+1.015	+0.477	<.001	.003	3	8
HNSC	BIN2 →	+0.728	+0.517	<.001	.001	3	7
HNSC	DOCK2 →	+0.580	+0.465	.002	.005	3	7
HNSC	CD226 →	+0.518	+0.539	.001	.001	3	7
UCEC	CRTAM →	+0.864	+0.435	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001773 vs CD53 — BRCA

Explore this scatter interactively →