Myeloid dendritic cell activation

Across TCGA cell cohorts, RNA activity of the Myeloid dendritic cell activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EML2, FBXL4, and TTC9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EML2 grouped by Myeloid dendritic cell activation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EML2 →	-1.078	-1.232	.001	<.001	3	4
STOMACH	FBXL4 →	-0.535	-0.935	<.001	.004	3	3
STOMACH	TTC9 →	-2.123	-1.130	.002	.007	3	3
STOMACH	LCA5 →	-1.176	-1.115	<.001	.005	3	3
STOMACH	SLC2A12 →	-2.458	-1.314	.003	<.001	3	3
BLOOD_Lymphoma	INPP5J →	-3.022	-1.857	.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EML2 by Myeloid dendritic cell activation activity — STOMACH

Explore this box plot interactively →