Myeloid dendritic cell activation

Across TCGA cell cohorts, RNA activity of the Myeloid dendritic cell activation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSEN54, TEX9, and H3C8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid dendritic cell activation activity versus TSEN54 in OVARY (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TSEN54 →	-1.221	-0.437	.002	.002	3	4
BLOOD_Leukemia	TEX9 →	-0.852	-0.254	<.001	<.001	3	4
BLOOD_Leukemia	H3C8 →	-0.416	-0.153	.001	.006	3	4
OVARY	TIMM44 →	+1.105	+0.467	.007	.002	3	3
OVARY	HFM1 →	-0.552	-0.504	.002	.003	3	3
OVARY	SLC16A14 →	-1.522	-0.406	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001773 vs TSEN54 — OVARY

Explore this scatter interactively →