Immunological synapse formation

Across TCGA patient cohorts, RNA activity of the Immunological synapse formation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MS4A6A, CD226, and GVINP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immunological synapse formation activity versus MS4A6A in GBM (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MS4A6A →	+0.863	+0.537	<.001	<.001	3	9
LSCC	CD226 →	+0.547	+0.601	<.001	<.001	3	9
HNSC	GVINP1 →	+1.130	+0.266	<.001	.001	3	9
HNSC	ARHGAP15 →	+1.005	+0.301	<.001	<.001	3	9
BRCA	GIMAP7 →	+0.843	+0.202	<.001	<.001	3	9
HNSC	P2RY10 →	+1.030	+0.303	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001771 vs MS4A6A — GBM

Explore this scatter interactively →