Immunological synapse formation

Across TCGA cell cohorts, RNA activity of the Immunological synapse formation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A23, CYB5R2, and AFG3L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A23 grouped by Immunological synapse formation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC25A23 →	+0.183	+0.215	.003	.005	3	4
LARGE_INTESTINE	CYB5R2 →	-0.209	-0.208	.004	.001	3	4
BREAST	AFG3L2 →	-0.617	-0.149	<.001	<.001	2	5
BREAST	CYC1 →	-0.382	-0.223	<.001	<.001	3	4
BREAST	LINC00518 →	-0.159	-0.119	.001	.004	3	4
BREAST	ZNF250 →	-0.300	-0.135	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A23 by Immunological synapse formation activity — LARGE_INTESTINE

Explore this box plot interactively →