Immunological synapse formation

Across TCGA cell cohorts, RNA activity of the Immunological synapse formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UTS2B, CPN1, and GMPPA, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immunological synapse formation activity versus UTS2B in BLOOD_Leukemia (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UTS2B →	+0.095	+0.348	.003	.002	3	1
BLOOD_Lymphoma	CPN1 →	+0.073	+0.277	<.001	.004	3	1
BLOOD_Lymphoma	GMPPA →	+0.507	+0.224	<.001	.007	3	1
BLOOD_Lymphoma	OR5C1 →	+0.036	+0.277	<.001	.004	3	1
BLOOD_Lymphoma	RIBC1 →	+0.477	+0.256	.004	<.001	3	1
BLOOD_Lymphoma	TEKT4 →	+0.033	+0.277	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001771 vs UTS2B — BLOOD_Leukemia

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