Establishment of lymphocyte polarity

Across TCGA patient cohorts, RNA activity of the Establishment of lymphocyte polarity pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDFY4, WIPF1, and ADA2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of lymphocyte polarity activity versus WDFY4 in HNSC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WDFY4 →	+0.531	+0.103	<.001	<.001	3	10
OV	WIPF1 →	+0.561	+0.079	<.001	<.001	3	10
OV	ADA2 →	+0.555	+0.068	<.001	<.001	3	10
HNSC	CLIC2 →	+0.561	+0.098	<.001	<.001	3	10
LSCC	IL16 →	+0.631	+0.111	<.001	<.001	3	10
LSCC	LCP1 →	+0.571	+0.109	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001767 vs WDFY4 — HNSC

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