Establishment of lymphocyte polarity

Across TCGA cell cohorts, RNA activity of the Establishment of lymphocyte polarity pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH9, CCR7, and PEX1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYH9 grouped by Establishment of lymphocyte polarity-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MYH9 →	-0.414	-1.522	<.001	<.001	3	11
CNS	CCR7 →	-0.324	-0.967	<.001	<.001	3	6
LUNG_SCLC	PEX1 →	-0.363	-1.581	.002	<.001	3	6
OVARY	BRD8 →	-0.185	-0.972	.002	.003	3	6
LUNG_SCLC	KRT12 →	-0.238	-1.322	.003	.004	3	6
BREAST	RPP25 →	-0.203	-1.105	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYH9 by Establishment of lymphocyte polarity activity — LIVER

Explore this box plot interactively →