Establishment of lymphocyte polarity

Across TCGA cell cohorts, RNA activity of the Establishment of lymphocyte polarity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A43, AP1G2, and TEFM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A43 grouped by Establishment of lymphocyte polarity-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SLC25A43 →	-2.775	-2.021	.001	<.001	3	4
BLOOD_Leukemia	AP1G2 →	-0.917	-1.291	.002	.004	3	4
PANCREAS	TEFM →	+0.861	+1.799	<.001	<.001	3	4
LUNG_NSCLC_LUSC	TRIM38 →	-1.171	-0.960	.004	.003	3	4
OVARY	MLH3 →	-0.472	-1.177	.007	<.001	3	4
OVARY	EID3 →	-1.172	-1.523	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A43 by Establishment of lymphocyte polarity activity — BONE

Explore this box plot interactively →