Membrane raft assembly

Across TCGA patient cohorts, RNA activity of the Membrane raft assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFTN1, TOP1, and AHNAK, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane raft assembly activity versus RFTN1 in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFTN1 →	+0.506	+0.091	<.001	.001	3	9
UCEC	TOP1 →	-0.366	-0.117	<.001	<.001	3	9
GBM	AHNAK →	+0.586	+0.139	<.001	<.001	3	9
GBM	UTRN →	+0.404	+0.137	<.001	<.001	3	9
BRCA	FLNA_S2152 →	+0.674	+0.039	<.001	.005	3	9
UCEC	AHNAK_S5448 →	+0.795	+0.115	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001765 vs RFTN1 — UCEC

Explore this scatter interactively →