Membrane raft assembly

Across TCGA patient cohorts, RNA activity of the Membrane raft assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPX, IL1RL1, and STEAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane raft assembly activity versus SRPX in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRPX →	+1.552	+0.375	<.001	.003	3	5
BRCA	IL1RL1 →	+0.608	+0.428	<.001	<.001	3	5
BRCA	STEAP4 →	+1.134	+0.276	<.001	<.001	3	5
BRCA	DAB2 →	+0.927	+0.312	<.001	.004	3	5
BRCA	TGFBR2 →	+0.804	+0.248	<.001	.001	3	5
BRCA	STX12 →	+0.533	+0.375	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001765 vs SRPX — BRCA

Explore this scatter interactively →