Membrane raft assembly

Across TCGA patient cohorts, RNA activity of the Membrane raft assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAV1_S37, ILF2, and RFTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane raft assembly activity versus CAV1_S37 in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAV1_S37 →	+0.954	+0.363	<.001	<.001	3	5
OV	ILF2 →	-0.496	-0.270	<.001	<.001	3	5
OV	RFTN1 →	+0.514	+0.216	<.001	<.001	3	4
UCEC	SGCD →	+0.804	+0.275	<.001	.002	3	4
UCEC	SNTB2 →	+0.530	+0.340	<.001	.005	2	5
OV	CAV1 →	+0.803	+0.210	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001765 vs CAV1_S37 — BRCA

Explore this scatter interactively →