Membrane raft assembly

Across TCGA cell cohorts, RNA activity of the Membrane raft assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB17, SLC16A8, and RTL10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB17 grouped by Membrane raft assembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAB17 →	+1.999	+0.812	.004	.008	3	6
OVARY	SLC16A8 →	+0.626	+0.953	.004	.002	3	5
BONE	RTL10 →	+0.651	+1.798	.006	.001	3	4
LUNG_SCLC	FBXO15 →	+0.882	+1.176	.009	.005	3	4
LUNG_SCLC	ZDHHC11 →	+2.047	+1.387	.001	<.001	3	4
STOMACH	TPD52L1 →	+2.969	+1.157	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB17 by Membrane raft assembly activity — BREAST

Explore this box plot interactively →