Neuron migration

Across TCGA patient cohorts, RNA activity of the Neuron migration pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCOLCE, CNPY4, and LTBP3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron migration activity versus PCOLCE in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PCOLCE →	+0.650	+0.020	<.001	<.001	3	8
UCEC	CNPY4 →	+0.463	+0.037	.004	.009	3	7
HNSC	LTBP3 →	+0.425	+0.026	<.001	.009	3	7
BRCA	TIMP2 →	+0.518	+0.014	.002	.004	3	7
PDAC	DPYSL3 →	+0.376	+0.029	.004	.001	3	7
BRCA	AEBP1 →	+0.703	+0.017	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001764 vs PCOLCE — CCRCC

Explore this scatter interactively →