Neuron migration

Across TCGA patient cohorts, RNA activity of the Neuron migration pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC45A1, CCDC184, and TEX38, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron migration activity versus SLC45A1 in BRCA (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC45A1 →	+1.670	+1.663	.001	<.001	3	2
BRCA	CCDC184 →	+0.823	+1.663	.002	<.001	3	2
BRCA	TEX38 →	+0.519	+1.663	.002	<.001	3	2
BRCA	FGFR1 →	+2.054	+1.663	.001	<.001	3	2
COAD	FUOM →	-0.653	-0.800	.005	.001	3	2
COAD	FAM66D →	+0.241	+1.084	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001764 vs SLC45A1 — BRCA

Explore this scatter interactively →