Neuron migration

Across TCGA cell cohorts, RNA activity of the Neuron migration pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF130, L1CAM, and SPOP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF130 grouped by Neuron migration-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RNF130 →	-0.186	-0.175	.005	.006	3	5
KIDNEY	L1CAM →	-0.279	-0.218	.001	.002	3	4
LARGE_INTESTINE	SPOP →	-0.124	-0.145	.004	<.001	3	4
BONE	NPSR1 →	-0.264	-0.304	<.001	.003	3	4
LUNG_SCLC	KCTD18 →	-0.165	-0.174	<.001	<.001	3	3
STOMACH	DNAJC2 →	+0.454	+0.229	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF130 by Neuron migration activity — SKIN

Explore this box plot interactively →