Organ induction

Across TCGA patient cohorts, RNA activity of the Organ induction pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRIP1_T989, DDX39A, and LMCD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organ induction activity versus BRIP1_T989 in GBM (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BRIP1_T989 →	-0.828	-0.073	.001	.006	3	6
BRCA	DDX39A →	-0.465	-0.056	<.001	<.001	3	6
CCRCC	LMCD1 →	+0.524	+0.049	<.001	<.001	3	6
BRCA	RIF1 →	-0.364	-0.038	<.001	<.001	3	6
UCEC	FZD1 →	+0.696	+0.087	<.001	.002	3	6
BRCA	TGFB1I1 →	+0.449	+0.037	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001759 vs BRIP1_T989 — GBM

Explore this scatter interactively →