Organ induction

Across TCGA cell cohorts, RNA activity of the Organ induction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA5, TAPBPL, and TICAM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANXA5 grouped by Organ induction-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA5 →	-0.982	-0.818	.001	.002	3	6
CNS	TAPBPL →	-1.862	-1.401	<.001	<.001	3	5
LUNG_NSCLC_LUSC	TICAM2 →	-2.220	-1.713	<.001	<.001	3	5
CNS	UBA7 →	-2.433	-1.392	<.001	<.001	3	5
LIVER	FLVCR1 →	+1.283	+1.309	.001	<.001	3	4
BONE	FNIP1 →	-0.945	-1.437	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANXA5 by Organ induction activity — BREAST

Explore this box plot interactively →