Organ induction

Across TCGA cell cohorts, RNA activity of the Organ induction pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TK2, MED15, and ACAD10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TK2 grouped by Organ induction-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TK2 →	+0.126	+0.133	.003	.003	2	5
SKIN	MED15 →	-0.145	-0.123	.003	.004	3	3
OESOPHAGUS	ACAD10 →	+0.138	+0.076	.006	.007	3	3
OESOPHAGUS	PAK3 →	+0.163	+0.099	.002	<.001	3	3
OESOPHAGUS	KHSRP →	+0.411	+0.124	.009	.004	3	3
LIVER	CHRNB4 →	-0.206	-0.237	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TK2 by Organ induction activity — SKIN

Explore this box plot interactively →