Somite specification

pathway activity — cross-omics
GO:0001757Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Somite specification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RASIP1_S41, TPPP3, and UTP15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCRASIP1_S41 →+0.450+0.063<.001.00137
CCRCCTPPP3 →+0.589+0.347.001.00937
BRCAUTP15 →-0.344-0.085<.001<.00137
GBMTOM1L2 →+0.271+0.107<.001<.00136
HNSCANK2 →+0.579+0.191<.001.00427
BRCAITIH5 →+0.541+0.061<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration