Somitogenesis

Across TCGA patient cohorts, RNA activity of the Somitogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGKV1-17, MYLK2, and PRUNE2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somitogenesis activity versus IGKV1-17 in LUAD (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IGKV1-17 →	-1.355	-0.722	.007	<.001	3	3
HNSC	MYLK2 →	+1.494	+0.561	<.001	<.001	3	3
HNSC	PRUNE2 →	+0.938	+0.430	<.001	<.001	3	3
HNSC	AMOT →	+1.258	+0.393	.001	.009	3	3
HNSC	SMTNL2 →	+1.323	+0.425	<.001	<.001	3	3
UCEC	PLEKHA7 →	+0.375	+0.720	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001756 vs IGKV1-17 — LUAD

Explore this scatter interactively →