Somitogenesis

Across TCGA cell cohorts, RNA activity of the Somitogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OMG, MOB3C, and CEACAM21, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OMG grouped by Somitogenesis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OMG →	+0.365	+1.948	.004	.008	3	2
KIDNEY	MOB3C →	+0.283	+1.987	.004	<.001	2	3
KIDNEY	CEACAM21 →	+0.195	+1.854	.008	.003	3	2
PANCREAS	ERF →	+0.355	+1.841	<.001	.001	3	2
LUNG_NSCLC_LUAD	MDH1B →	+0.192	+1.072	<.001	.004	3	2
PANCREAS	TNFRSF14 →	+0.366	+2.220	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OMG by Somitogenesis activity — KIDNEY

Explore this box plot interactively →