Eye photoreceptor cell differentiation

Across TCGA patient cohorts, RNA activity of the Eye photoreceptor cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYRIA, SPAG1_S418, and ADGRG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eye photoreceptor cell differentiation activity versus CYRIA in HNSC (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYRIA →	-0.401	-0.046	<.001	<.001	3	7
COAD	SPAG1_S418 →	+0.885	+0.029	<.001	<.001	3	6
HNSC	ADGRG1 →	+0.547	+0.043	.003	.005	3	6
COAD	CDH1 →	+0.379	+0.027	<.001	<.001	2	7
COAD	FKBP15 →	-0.122	-0.022	.005	.004	3	6
HNSC	IL16 →	-0.458	-0.030	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001754 vs CYRIA — HNSC

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